Anti-N-Methyl-d-Aspartate Receptor Encephalitis: Early Treatment is Beneficial
Received 20 July 2009; accepted 12 October 2009.
Anti-N-methyl-d-aspartate receptor antibody has been associated with a severe stereotypic form of subacute encephalitis, often found in women with ovarian teratoma. Reported here is the diagnosis of anti-N-methyl-d-aspartate receptor encephalitis in a 5-year-old girl who presented with subacute encephalopathy and movement disorder without evidence of malignancy. Early diagnosis and treatment with immune globulin and steroids resulted in near-complete recovery.
∗Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana
§Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana
†Division of Neuro-oncology, Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania
‡Departments of Neurology, Immunology, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
Communications should be addressed to: Dr. Sokol; Riley Hospital for Children; Department of Neurology XE40; Indiana University School of Medicine; 575 West Drive; Indianapolis, IN, 46202.
ABSTRACT