Pediatric Neurology
Volume 42, Issue 3 , Pages 219-222 , March 2010

Intracerebral Blood and MRS in Neonatal Nonketotic Hyperglycinemia

  • Brett J. Manley, MBBS

      Affiliations

    • Department of Neonatal Services, Royal Women's Hospital, Parkville, Victoria, Australia
    • ,
  • Jenni Sokol, MBBS

      Affiliations

    • Department of Neonatal Services, Royal Women's Hospital, Parkville, Victoria, Australia
    • Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia
    • ,
  • Jeanie L.Y. Cheong, MD

      Affiliations

    • Department of Neonatal Services, Royal Women's Hospital, Parkville, Victoria, Australia
    • Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia
    • Corresponding Author InformationCommunications should be addressed to: Dr. Cheong; Royal Women's Hospital; Level 7, Newborn Research; 20 Flemington Road; Parkville, Victoria 3052, Australia.

Received 27 May 2009 ,Accepted 26 October 2009.

References 

  1. Kikuchi G, Motokawa Y, Yoshida T, Hiraga K. Glycine cleavage system: Reaction mechanism, physiological significance, and hyperglycinemia. Proc Jpn Acad [B] Phys Biol Sci. 2008;84:246–263
  2. Volpe JJ. Neurology of the newborn. 5th ed.. Philadelphia: Saunders Elsevier; 2008;659-67
  3. Heindel W, Kugel H, Roth B. Noninvasive detection of increased glycine content by proton MR spectroscopy in the brains of two infants with nonketotic hyperglycinemia. AJNR. 1993;14:629–635
  4. Huisman TAGM, Thiel T, Steinmann B, Zeilinger G, Martin E. Proton magnetic resonance spectroscopy of the brain of a neonate with nonketotic hyperglycinemia: in vivo-in vitro (ex vivo) correlation. Eur Radiol. 2002;12:858–861
  5. Gabis L, Parton P, Roche P, Lenn N, Tudorica A, Huang W. In vivo 1H magnetic resonance spectroscopy measurement of brain glycine levels in nonketotic hyperglycinemia. J Neuroimag. 2001;11:209–211
  6. Korman SH, Gutman A. Pitfalls in the diagnosis of glycine encephalopathy (non-ketotic hyperglycinaemia). Dev Med Child Neurol. 2002;44:712–720
  7. Hoover-Fong JE, Shah S, Van Hove JL, Applegarth D, Toone J, Hamosh A. Natural history of nonketotic hyperglycinaemia in 65 patients. Neurology. 2004;63:1847–1853
  8. Aliefendioglu D, Aslan AT, Coskun T, Dursun A, Cakmak FN, Kesimer M. Transient nonketotic hyperglycinemia: Two case reports and literature review. Pediatr Neurol. 2003;28:151–155
  9. Zammarchi E, Donati MA, Ciani F. Transient neonatal nonketotic hyperglycinaemia: A 13-year follow-up. Neuropediatrics. 1995;26:328–330
  10. Shah DK, Tingay DG, Fink AM, Hunt RW, Dargaville PA. Magnetic resonance imaging in neonatal nonketotic hyperglycinemia. Pediatr Neurol. 2005;33:50–52
  11. Patay Z, Robertson NJ, Cox IJ. Metabolic disorders in the neonate. In:  Rutherford MA editors. MRI of the neonatal brain. London: W.B. Saunders; 2002;p. 317–347
  12. Choi C-G, Lee HK, Yoon J-H. Localised proton MR spectroscopic detection of nonketotic hyperglycinaemia in an infant. Korean J Radiol. 2001;2:239–242
  13. Khong P-L, Lam BCC, Chung BHY, Wong K-Y, Ooi G-C. Diffusion-weighted MR imaging in neonatal nonketotic hyperglycinemia. AJNR. 2003;24:1181–1183
  14. Mourmans J, Majoie CBLM, Barth PG, Duran M, Akkerman EM, Poll-The BT. Sequential MR imaging changes in nonketotic hyperglycinemia. AJNR. 2006;27:208–211

PII: S0887-8994(09)00531-1

doi: 10.1016/j.pediatrneurol.2009.10.013

Pediatric Neurology
Volume 42, Issue 3 , Pages 219-222 , March 2010

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