Pediatric Neurology
Volume 42, Issue 6 , Pages 413-416 , June 2010

Pattern of Cerebrospinal Fluid Lactic Dehydrogenase During Treatment of Bacterial Meningitis

  • Udi Nussinovitch, MD

      Affiliations

    • Department of Internal Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationCommunications should be addressed to: Dr. M. Nussinovitch; Department of Pediatrics C, Schneider Children's Medical Center of Israel; Petach Tikva 49202, Israel.
    • ,
  • Yaron Finkelstein, MD

      Affiliations

    • Division of Clinical Pharmacology and Toxicology and Division of Emergency Medicine, Department of Pediatrics, Hospital for Sick Children, Ontario, Canada
    • ,
  • Daniella Harel, PhD

      Affiliations

    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Laboratory of Clinical Chemistry, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    • ,
  • Naomi Nussinovitch, MD

      Affiliations

    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Department of Internal Medicine D, Chaim Sheba Medical Center, Tel Hashomer, Israel
    • ,
  • Moshe Nussinovitch, MD

      Affiliations

    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikva, Israel

References 

  1. Scarborough M, Thwaites GE. The diagnosis and management of acute bacterial meningitis in resource-poor settings. Lancet Neurol. 2008;7:637–648
  2. Kamat DV, Chakravorty BP. Comparative values of CSF-LDH isoenzymes in neurological disorders. Indian J Med Sci. 1999;53:1–6
  3. Neches W, Platt M. Cerebrospinal fluid LDH in 287 children, including 53 cases of meningitis of bacterial and non-bacterial etiology. Pediatrics. 1968;41:1097–1103
  4. Feldman WE. Cerebrospinal fluid lactic acid dehydrogenase activity. Levels in untreated and partially antibiotic-treated meningitis. Am J Dis Child. 1975;129:77–80
  5. Beaty HN, Oppenheimer S. Cerebrospinal-fluid lactic dehydrogenase and its isoenzymes in infections of the central nervous system. N Engl J Med. 1968;279:1197–1202
  6. Nussinovitch M, Harel D, Eidlitz-Markus T, Amir J, Volovitz B. Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with infantile spasms. Eur Neurol. 2003;49:231–233
  7. Nussinovitch M, Prais D, Finkelstein Y, Harel D, Amir J, Volovitz B. Lactic dehydrogenase isoenzymes in cerebrospinal fluid of children with Guillain-Barre syndrome. Arch Dis Child. 2002;87:255–256
  8. Nussinovitch M, Volovitz B, Finkelstein Y, Amir J, Harel D. Lactic dehydrogenase isoenzymes in cerebrospinal fluid associated with hydrocephalus. Acta Paediatr. 2001;90:972–974
  9. Politi Elishkevitz K, Nussinovitch U, Nussinovitch M. LDH isoenzymes in adolescents with multiple sclerosis. Pediatr Neurol. 2009;41:259–262
  10. Nussinovitch M, Finkelstein Y, Politi Elishkevitz K, et al. Cerebrospinal fluid LDH isoenzymes in children with bacterial and aseptic meningitis. Translational Res. 2009;154:214–218
  11. Nelson PV, Carey WF, Pollard AC. Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders. J Clin Pathol. 1975;28:828–833
  12. Lutsar I, Haldre S, Topman M, Talvik T. Enzymatic changes in the cerebrospinal fluid in patients with infections of the central nervous system. Acta Paediatr. 1994;83:1146–1150
  13. Nussinovitch M, Prais D, Volovitz B, Amir J, Harel D, Nussinovitch A. Reference values for lactic dehydrogenase activity and isoenzyme distribution in cerebrospinal fluid in neonates with fever but no evidence of cerebral disease. Am J Perinatol. 2002;19:109–114
  14. Wroblewski F, Decker B, Wroblewski R. The clinical implications of spinal-fluid lactic dehydrogenase activity. N Engl J Med. 1958;258:635–639

PII: S0887-8994(10)00036-6

doi: 10.1016/j.pediatrneurol.2010.01.013

Pediatric Neurology
Volume 42, Issue 6 , Pages 413-416 , June 2010

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