Pediatric Neurology
Volume 42, Issue 6 , Pages 396-403 , June 2010

Efficacy of Felbamate in the Treatment of Intractable Pediatric Epilepsy

  • Mary L. Zupanc, MD

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • Department of Pediatrics, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • Corresponding Author InformationCommunications should be addressed to: Dr. Zupanc; Children's Hospital of Wisconsin; 9000 W. Wisconsin Ave.; CHW CCC Suite C540; Milwaukee, WI 53201.
    • ,
  • Rhonda Roell Werner, RN, CNS

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Michael S. Schwabe, MD

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Sunila E. O'Connor, MD

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Charles J. Marcuccilli, MD, PhD

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Kurt E. Hecox, MD, PhD

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Maria S. Chico, RN, CPNP

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Kathy A. Eggener, RN, CPNP

      Affiliations

    • Department of Neurology, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Received 20 July 2009 ,Accepted 11 February 2010.

References 

  1. Brodie MJ. Felbamate: a new antiepileptic drug. Lancet. 1993;341:1445–1446
  2. Beghi E. Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines. Lancet Neurol. 2004;3:618–621
  3. Pharmaceuticals Meda. Felbatol [package insert]. Somerset, NJ: Meda Pharmaceuticals; 2003;
  4. Pennell PB, Ogaily MS, Macdonald RL. Aplastic anemia in a patient receiving felbamate for complex partial seizures. Neurology. 1995;45:456–460
  5. Swinyard EA, Sofia RD, Kupferberg HJ. Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats. Epilepsia. 1986;27:27–34
  6. White HS. Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs. Epilepsia. 1999;40(Suppl. 5):S2–10
  7. Sankar R, Holmes GL. Mechanisms of action for the commonly used antiepileptic drugs: relevance to antiepileptic drug-associated neurobehavioral adverse effects. J Child Neurol. 2004;19(Suppl. 1):S6–14
  8. Faught E, Sachdeo RC, Remler MP, et al. Felbamate monotherapy for partial-onset seizures: an active-control trial. Neurology. 1993;43:688–692
  9. Sachdeo R, Kramer LD, Rosenberg A, Sachdeo S. Felbamate monotherapy: controlled trial in patients with partial onset seizures. Ann Neurol. 1992;32:386–392
  10. Devinsky O, Faught RE, Wilder BJ, et al. Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures. Epilepsy Res. 1995;20:241–246
  11. Bourgeois B, Leppik IE, Sackellares JC, et al. Felbamate: a double-blind controlled trial in patients undergoing presurgical evaluation of partial seizures. Neurology. 1993;43:693–696
  12. Felbamate Study Group in Lennox-Gastaut Syndrome. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). N Engl J Med. 1993;328:29–33
  13. Dodson WE. Felbamate in the treatment of Lennox-Gastaut syndrome: results of a 12-month open-label study following a randomized clinical trial. Epilepsia. 1993;34(Suppl. 7):S18–S24
  14. Kaufman DW, Kelly JP, Anderson T, Harmon DC, Shapiro S. Evaluation of cases of aplastic anemia among patients treated with felbamate. Epilepsia. 1997;38:1265–1269
  15. Pellock JM, Faught E, Leppik IE, Shinnar S, Zupanc ML. Felbamate: consensus of current clinical experience. Epilepsy Res. 2006;71:89–101
  16. Pellock JM, Brodie MJ. Felbamate: 1997 update. Epilepsia. 1997;38:1261–1264
  17. Hitiris N, Mohanraj R, Norrie J, Brodie MJ. Mortality in epilepsy. Epilepsy Behav. 2007;10:363–376

PII: S0887-8994(10)00094-9

doi: 10.1016/j.pediatrneurol.2010.02.013

Pediatric Neurology
Volume 42, Issue 6 , Pages 396-403 , June 2010

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