Pediatric Neurology
Volume 43, Issue 1 , Pages 25-28 , July 2010

APOE Gene ε Polymorphism Does Not Determine Predisposition to Ischemic Stroke in Children

  • Anna Balcerzyk, PhD

      Affiliations

    • Department of Biochemistry and Medical Genetics, School of Health Care, Medical University of Silesia, Katowice, Poland
    • Corresponding Author InformationCommunications should be addressed to: Dr. Balcerzyk; Department of Biochemistry and Medical Genetics; Medical University of Silesia; Medyków 18; 40-752 Katowice, Poland.
    • ,
  • Iwona Żak, PhD

      Affiliations

    • Department of Biochemistry and Medical Genetics, School of Health Care, Medical University of Silesia, Katowice, Poland
    • ,
  • Paweł Niemiec, PhD

      Affiliations

    • Department of Biochemistry and Medical Genetics, School of Health Care, Medical University of Silesia, Katowice, Poland
    • ,
  • Ilona Kopyta, PhD

      Affiliations

    • Department of Neuropediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
    • ,
  • Ewa Emich-Widera, PhD

      Affiliations

    • Department of Neuropediatrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
    • ,
  • Tomasz Iwanicki, MSc

      Affiliations

    • Department of Biochemistry and Medical Genetics, School of Health Care, Medical University of Silesia, Katowice, Poland

Received 2 December 2009 ,Accepted 11 February 2010.

References 

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  2. Nowak-Göttl U, Günther G, Kurnik K, Sträter R, Kirkham F. Arterial ischemic stroke in neonates, infants, and children: an overview of underlying conditions, imaging methods, and treatment modalities. Semin Thromb Hemost. 2003;29:405–414
  3. Brass LM, Isaacsohn JL, Merikangas KR, Robinette CD. A study of twins and stroke. Stroke. 1992;23:221–223
  4. Kopyta I, Marszał E. Risk factors of ischemic stroke in children: I. Selected biochemical and immunological risk factors of ischemic stroke in children [In Polish]. Udar Mozgu. 2004;6:47–55
  5. Kopyta I, Marszał E. Risk factors of ischemic stroke in children: II. Lipid metabolism abnormalities in etiopathogenesis of ischemic stroke in children [In Polish]. Udar Mozgu. 2004;6:57–64
  6. Balcerzyk A, Żak I. Apolipoprotein E: the role of polymorphism in pathogenesis of many diseases [In Polish]. Postepy Biochem. 2004;50:344–352
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  9. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 1990;31:545–548
  10. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet. 1993;52:506–516
  11. Graham I, Atar D, Borch-Johnsen K, et al. Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J. 2007;28:2375–2414
  12. Simma B, Martin G, Müller T, Huemer M. Risk factors for pediatric stroke: consequences for therapy and quality of life. Pediatr Neurol. 2007;37:121–126
  13. McCarron MO, Delong D, Alberts MJ. APOE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis. Neurology. 1999;53:1308–1311
  14. Slowik A, Iskra T, Turaj W, Hartwich J, Dembinska-Kiec A, Szczudlik A. LDL phenotype B and other lipid abnormalities in patients with large vessel disease and small vessel disease. J Neurol Sci. 2003;214:11–16
  15. Balcerzyk A, Zak I, Krauze J. Protective effect of R allele of PON1 gene on the coronary artery disease in the presence of specific genetic background. Dis Markers. 2008;24:81–88
  16. Bednarska-Makaruk M, Broda G, Kurjata P, et al. Apolipoprotein E genotype, lipid levels and coronary heart disease in a Polish population group. Eur J Epidemiol. 2001;17:789–792
  17. Weir CJ, McCarron MO, Muir KW, et al. Apolipoprotein E genotype, coagulation, and survival following acute stroke. Neurology. 2001;57:1097–1100

PII: S0887-8994(10)00097-4

doi: 10.1016/j.pediatrneurol.2010.02.016

Pediatric Neurology
Volume 43, Issue 1 , Pages 25-28 , July 2010

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