Pediatric Neurology
Volume 43, Issue 1 , Pages 29-34 , July 2010

Vagus Nerve Stimulation for Refractory Epilepsy in Tuberous Sclerosis

  • Nelia Zamponi, MD

      Affiliations

    • Pediatric Neurology Department, Ospedali Riuniti, Ancona, Italy
    • Corresponding Author InformationCommunications should be addressed to: Dr. Zamponi; Pediatric Neurology Department; Ospedali Riuniti; via Corridoni 11, Ancona, Italy.
    • ,
  • Cristina Petrelli, MD

      Affiliations

    • Pediatric Neurology Department, Ospedali Riuniti, Ancona, Italy
    • ,
  • Claudia Passamonti, MD

      Affiliations

    • Pediatric Neurology Department, Ospedali Riuniti, Ancona, Italy
    • ,
  • Romina Moavero, MD

      Affiliations

    • Neuroscience Department, Pediatric Neurology Unit, University of Rome “Tor Vergata,” Rome, Italy
    • ,
  • Paolo Curatolo, MD

      Affiliations

    • Neuroscience Department, Pediatric Neurology Unit, University of Rome “Tor Vergata,” Rome, Italy

Received 23 December 2009 ,Accepted 1 March 2010.

References 

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  2. Napolioni V, Moavero R, Curatolo P. Recent advances in neurobiology of tuberous sclerosis complex. Brain Dev. 2008;31:104–113
  3. Holmes GL, Stafstrom CE Tuberous Sclerosis Study Group. Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia. 2007;48:617–630
  4. Curatolo P, Bombardieri R, Verdecchia M, Seri S. Intractable seizures in tuberous sclerosis complex: from molecular pathogenesis to the rationale for treatment. J Child Neurol. 2005;20:318–325
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  7. Saneto RP, Sotero de Menezes MA, Ojemann JG, et al. Vagus nerve stimulation for intractable seizures in children. Pediatr Neurol. 2006;35:323–326
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  10. McHugh JC, Singh HW, Phillips J, Murphy K, Doherty CP, Delanty N. Outcome measurement after vagal nerve stimulation therapy: proposal of a new classification. Epilepsia. 2007;48:375–378
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  12. Major P, Thiele EA. Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex. Epilepsy Behav. 2008;13:357–360
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  14. Parain D, Penniello MJ, Berquen P, Delangre T, Billard C, Murphy JV. Vagal nerve stimulation in tuberous sclerosis complex patients. Pediatr Neurol. 2001;25:213–216
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  16. Hallböök T, Lundgren J, Stjernqvist K, Blennow G, Strömblad LG, Rosén I. Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood. Seizure. 2005;14:504–513
  17. Bombardieri R, Pinci M, Moavero R, Cerminara C, Curatolo P. Early control of seizures improves long-term outcome in children with tuberous sclerosis complex. Eur J Paediatr Neurol. 2009;14:146–149
  18. Zamponi N, Rychlicki F, Corpaci L, Cesaroni E, Trignani R. Vagus nerve stimulation (VNS) is effective in treating catastrophic epilepsy in very young children. Neurosurg Rev. 2008;31:291–297
  19. White R, Hua Y, Scheithauer B, Lynch DR, Henske EP, Crino PB. Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol. 2001;49:67–78
  20. Valencia I, Legido A, Yelin K, Khurana D, Kothare SV, Katsetos CD. Anomalous inhibitory circuits in cortical tubers of human tuberous sclerosis complex associated with refractory epilepsy: aberrant expression of parvalbumin and calbindin-D28k in dysplastic cortex. J Child Neurol. 2006;21:1058–1063
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  22. Vonck K, De Herdt V, Bosman T, Dedeurwaerdere S, Van Laere K, Boon P. Thalamic and limbic involvement in the mechanism of action of vagus nerve stimulation, a SPECT study. Seizure. 2008;17:699–706
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PII: S0887-8994(10)00100-1

doi: 10.1016/j.pediatrneurol.2010.03.003

Pediatric Neurology
Volume 43, Issue 1 , Pages 29-34 , July 2010

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