Pediatric Neurology
Volume 46, Issue 2 , Pages 70-76 , February 2012

Diurnal Melatonin Patterns in Children: Ready to Apply in Clinical Practice?

  • Rūta Praninskienė, MD

      Affiliations

    • Department of Pediatric Neurology, Vilnius University Children's Hospital, Vilnius, Lithuania
  • ,
  • Irena Dumalakienė, PhD

      Affiliations

    • Department of Immunology, State Research Institute Center for Innovative Medicine, Vilnius, Lithuania
  • ,
  • Robertas Kemežys, MD

      Affiliations

    • Faculty of Medicine, Vilnius University, Vilnius, Lithuania
  • ,
  • Mykolas Mauricas, PhD

      Affiliations

    • Department of Immunology, State Research Institute Center for Innovative Medicine, Vilnius, Lithuania
  • ,
  • Aurelija Jučaitė, MD, PhD

      Affiliations

    • Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationCommunications should be addressed to: Dr. Jučaitė; Department of Neuropediatrics; Astrid Lindgrens Barnsjukhus; S-171 76 Stockholm, Sweden.

Received 25 June 2011 ,Accepted 29 November 2011.

References 

  1. Axelrod J. The pineal gland: A neurochemical transducer. Science. 1974;184:1341–1348
  2. Bubenik GA. Gastrointestinal melatonin: Localization, function, and clinical relevance. Dig Dis Sci. 2002;47:2336–2348
  3. Slominski A, Fischer TW, Zmijewski MA, et al. On the role of melatonin in skin physiology and pathology. Endocrine. 2005;27:137–148
  4. Dijk DJ, Cajochen C. Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. J Biol Rhythms. 1997;12:627–635
  5. Srinivasan V, Pandi-Perumal SR, Trakht I, et al. Pathophysiology of depression: Role of sleep and the melatonergic system. Psychiatry Res. 2009;165:201–214
  6. Cernysiov V, Gerasimcik N, Mauricas M, Girkontaite I. Regulation of T-cell-independent and T-cell-dependent antibody production by circadian rhythm and melatonin. Int Immunol. 2010;22:25–34
  7. Van der Heijden KB, Smits MG, Van Someren EJ, Gunning WB. Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: A circadian rhythm sleep disorder. Chronobiol Int. 2005;22:559–570
  8. Weiss MD, Salpekar J. Sleep problems in the child with attention-deficit hyperactivity disorder: Defining aetiology and appropriate treatments. CNS Drugs. 2010;24:811–828
  9. Olivier P, Fontaine RH, Loron G, et al. Melatonin promotes oligodendroglial maturation of injured white matter in neonatal rats. PLoS One. 2009;4:e7128
  10. Sandyk R. Alpha rhythm and the pineal gland. Int J Neurosci. 1992;63:221–227
  11. Kulman G, Lissoni P, Rovelli F, Roselli MG, Brivio F, Sequeri P. Evidence of pineal endocrine hypofunction in autistic children. Neurol Endocrinol Lett. 2000;21:31–34
  12. Tordjman S, Anderson GM, Pichard N, Charbuy H, Touitou Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biol Psychiatry. 2005;57:134–138
  13. Gitto E, Aversa S, Reiter RJ, Barberi I, Pellegrino S. Update on the use of melatonin in pediatrics. J Pineal Res. 2011;50:21–28
  14. Laakso ML, Porkka-Heiskanen T, Alila A, Stenberg D, Johansson G. Correlation between salivary and serum melatonin: Dependence on serum melatonin levels. J Pineal Res. 1990;9:39–50
  15. Nowak R, McMillen IC, Redman J, Short RV. The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: Two non-invasive techniques for monitoring human circadian rhythmicity. Clin Endocrinol (Oxf). 1987;27:445–452
  16. Miles A, Philbrick D, Tidmarsh SF, Shaw DM. Direct radioimmunoassay of melatonin in saliva. Clin Chem. 1985;31:1412–1413
  17. Ardura J, Gutierrez R, Andres J, Agapito T. Emergence and evolution of melatonin in children. Horm Res. 2003;59:66–72
  18. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969;44:291–303
  19. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child. 1970;45:13–23
  20. Bruni O, Ottaviano S, Guidetti V, et al. The Sleep Disturbance Scale for Children (SDSC): Construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence. J Sleep Res. 1996;5:251–261
  21. Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C. Sensitivity of the human circadian pacemaker to nocturnal light: Melatonin phase resetting and suppression. J Physiol (Lond). 2000;526:695–702
  22. Voultsios A, Kennaway DJ, Dawson D. Salivary melatonin as a circadian phase marker: Validation and comparison to plasma melatonin. J Biol Rhythms. 1997;12:457–466
  23. Griefahn B, Brode P, Blaszkewicz M, Remer T. Melatonin production during childhood and adolescence: A longitudinal study on the excretion of urinary 6-hydroxymelatonin sulfate. J Pineal Res. 2003;34:26–31
  24. Touitou Y, Auzéby A, Camus F, Djeridane Y. Daily profiles of salivary and urinary melatonin and steroids in healthy prepubertal boys. J Pediatr Endocrinol Metab. 2009;22:1009–1015
  25. Pääkkönen T, Mäkinen TM, Leppäluoto J, et al. Urinary melatonin: A noninvasive method to follow human pineal function as studied in three experimental conditions. J Pineal Res. 2006;40:110–115
  26. Burgess HJ, Fogg LF. Individual differences in the amount and timing of salivary melatonin secretion. PLoS One. 2008;3:e3055
  27. Wetterberg L, Bergiannaki JD, Paparrigopoulos T, et al. Normative melatonin excretion: A multinational study. Psychoneuroendocrinology. 1999;24:209–226
  28. Wetterberg L, Iselius L, Lindsten J. Genetic regulation of melatonin excretion in urine: A preliminary report. Clin Genet. 1983;24:399–402
  29. Hallam KT, Olver JS, Chambers V, Begg DP, McGrath C, Norman TR. The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins. Psychoneuroendocrinology. 2006;31:867–875
  30. Blomeke B, Golka K, Griefahn B, Roemer HC. Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis. J Toxicol Environ Health [A]. 2008;71:874–876
  31. Kennaway DJ, Goble FC, Stamp GE. Factors influencing the development of melatonin rhythmicity in humans. J Clin Endocrinol Metab. 1996;81:1525–1532
  32. Attanasio A, Rager K, Gupta D. Ontogeny of circadian rhythmicity for melatonin, serotonin, and N-acetylserotonin in humans. J Pineal Res. 1986;3:251–256
  33. Waldhauser F, Wieszenbacher G, Tatzer E, et al. Alterations in nocturnal serum melatonin levels in humans with growth and aging. J Clin Endocrinol Metab. 1988;66:648–652
  34. Kennaway DJ, Lushington K, Dawson D, Lack L, van den Heuvel C, Rogers N. Urinary 6-sulfatoxymelatonin excretion and aging: New results and a critical review of the literature. J Pineal Res. 1999;27:210–220
  35. Chik CL, Rollag MD, Duncan WC, Smith AC. Diagnostic utility of daytime salivary melatonin levels in Smith-Magenis syndrome. Am J Med Genet [A]. 2010;152A:96–101
  36. Waldhauser F, Wieszenbacher G, Zeitlhuber U, Waldhauser M, Frisch H, Wurtmann RJ. Fall in nocturnal serum melatonin levels during prepuberty and pubescence. Lancet. 1984;1:362–365
  37. Salti R, Galluzzi F, Bindi G, et al. Nocturnal melatonin patterns in children. J Clin Endocrinol Metab. 2000;85:2137–2144
  38. Young IM, Francis PL, Leone AM, Stovell P, Silman RE. Constant pineal output and increasing body mass account for declining melatonin levels during human growth and sexual maturation. J Pineal Res. 1988;5:71–85
  39. Markey SP, Higa S, Shih M, Danforth DN, Tamarkin L. The correlation between human plasma melatonin levels and urinary 6-hydroxymelatonin excretion. Clin Chim Acta. 1985;150:221–225
  40. Bojkowski CJ, Arendt J, Shih MC, Markey SP. Melatonin secretion in human assessed by measuring its metabolite, 6-sulfatoxymelatonin. Clin Chem. 1987;33:1343–1348
  41. Miles A, Philbrick DR, Thomas DR, Grey J. Diagnostic and clinical implications of plasma and salivary melatonin assay. Clin Chem. 1987;33:1295–1297
  42. Benloucif S, Burgess HJ, Klerman EB, et al. Measuring melatonin in humans. J Clin Sleep Med. 2008;4:66–69
  43. Laakso ML, Leinonen L, Hätönen T, Alila A. Melatonin, cortisol and body temperature rhythms in Lennox-Gastaut patients with or without circadian rhythm sleep disorders. J Pineal Res. 1993;15:21–26
  44. Leu RM, Beyderman L, Botzolakis EJ, Surdyka K, Wang L, Malow BA. Relation of melatonin to sleep architecture in children with autism. J Autism Dev Disord. 2011;41:427–433
  45. Debus OM, Lerchl A, Bothe HW, et al. Spontaneous central melatonin secretion and resorption kinetics of exogenous melatonin: A ventricular CSF study. J Pineal Res. 2002;33:213–217
  46. Jan JE, Reiter RJ, Bax MC, Ribary U, Freeman RD, Wasdell MB. Long-term sleep disturbances in children: A cause of neuronal loss. Eur J Paediatr Neurol. 2010;14:380–390
  47. Rivas-Martínez I, Ambite-Quesada S, Fernández-de-Las-Peñas C, et al. Salivary cortisol and melatonin levels in children with frequent episodic tension-type headache do not differ from healthy children. Acta Paediatr Scand. 2011;100:e198–e202
  48. van Geijlswijk IM, Korzilius HP, Smits MG. The use of exogenous melatonin in delayed sleep phase disorder: A meta-analysis. Sleep. 2010;33:1605–1614
  49. Masruha MR, Lin J, de Souza Vieira DS, et al. Urinary 6-sulphatoxymelatonin levels are depressed in chronic migraine and several comorbidities. Headache. 2010;50:413–419
  50. Knook L, Kavelaars A, Sinnema G, Kuis W, Heijnen CJ. High nocturnal melatonin in adolescents with chronic fatigue syndrome. J Clin Endocrinol Metab. 2000;85:3690–3692

PII: S0887-8994(11)00505-4

doi: 10.1016/j.pediatrneurol.2011.11.018

Pediatric Neurology
Volume 46, Issue 2 , Pages 70-76 , February 2012