Abstract
Background
Facial angiofibromas are present in most of the patients with the tuberous sclerosis
complex and may cause severe disfiguration of the face. The tumor growth in tuberous
sclerosis complex is promoted by the disinhibition of the mammalian target of rapamycin
pathway. Thus, the systemic treatment with mammalian target of rapamycin inhibitors
such as sirolimus and everolimus has recently been established to treat specific tuberous
sclerosis complex–associated lesions. For patients who suffer from disfiguring facial
angiofibromas only, there is a need for a topical use of mammalian target of rapamycin
inhibitors. Sirolimus has been shown to be beneficial in treating facial angiofibromas.
But the topical use of everolimus, which has the approval to treat tuberous sclerosis
complex–associated tumors, namely giant cell astrocytomas and renal angiofibromas,
has not been reported.
Patients and Results
We present a 10-year-old girl whose facial angiofibromas were successfully treated
with an everolimus ointment without relevant side effects. In addition, we provide
a short pharmacological overview of sirolimus and everolimus with focus on the topical
use.
Conclusions
Topical everolimus seems to be a favorable and safe option for patients with facial
angiofibromas who do not require systemic treatment.
Keywords
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Article info
Publication history
Published online: March 03, 2014
Accepted:
February 19,
2014
Received:
October 11,
2013
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
