Abstract
Background
Epileptic encephalopathy with electrical status epilepticus during sleep is an age-related
and self-limited disorder. The present study analyzed the etiology, demographics,
and pathogenesis of patients with electrical status epilepticus during sleep to provide
information on the diagnosis and therapy of this syndrome.
Methods
The etiologies of epileptic encephalopathy with electrical status epilepticus during
sleep in patients admitted in Chinese People's Liberation Army General Hospital from
2009 to 2014 were retrospectively analyzed. Patients were classified into the genetic,
structural-metabolic, and unknown groups according to the etiology. Demographics and
clinical characteristics of all the patients were then analyzed and compared among
groups.
Results
The etiologies of epileptic encephalopathy with electrical status epilepticus during
sleep in 75 patients mainly included benign childhood epilepsy with centrotemporal
spikes, Landau-Kleffner syndrome, polymicrogyria, and migration disorders. Age at
onset of epilepsy did not show a specific pattern, but age at onset of epileptic encephalopathy
with electrical status epilepticus during sleep was concentrated at age 6-9 years.
The mean age at onset of epilepsy in the genetic group was significantly older than
that in the structural-metabolic group (P < 0.05). Age at onset of epileptic encephalopathy with electrical status epilepticus
during sleep did not significantly differ between the two groups.
Conclusions
Electrical status epilepticus during sleep is an epileptic encephalopathy related
to brain development and presents an age-dependent occurrence.
Keywords
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Article info
Publication history
Published online: December 18, 2015
Accepted:
December 13,
2015
Received:
July 7,
2015
Footnotes
Grant numbers and sources of support: This work was supported by grants from the Major State Basic Research Development Program (973; No. 2012CB517903), the National Natural Science Foundation of China (nos. 81471329) and Public health program of Capital (Z141100002114001).
Identification
Copyright
© 2016 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
