Advertisement

Letter reply

      We thank Drs. Thiwari and Kumar for their interest on our two recent publications related to our randomized single blind clinical trial conducted to describe the electroencephalographic (EEG) outcome
      • Wanigasinghe J.
      • Arambepola C.
      • Sri Ranganathan S.
      • Sumanasena S.
      • Muhandiram E.
      The Efficacy of Moderate-to-High Dose Oral Prednisolone Versus Low-to-Moderate Dose Intramuscular Corticotropin for Improvement of Hypsarrhythmia in West Syndrome : A Randomized, Single-lind, Parallel Clinical Trial.
      as well as the immediate and short term spasm outcome
      • Wanigasinghe J.
      • Arambepola C.
      • Sri Ranganathan S.
      • Sumanasena S.
      • Attanapola G.
      Randomized, Single-Blind, Parallel Clinical Trial on Efficacy of Oral Prednisolone Versus Intramuscular Corticotropin on Immediate and Continued Spasm Control in West Syndrome.
      in children with West syndrome when treated with oral prednisolone versus intramuscular adrenocorticotrophic hormone (ACTH). We have tried to clarify the main points raised in their letter below.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Pediatric Neurology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Wanigasinghe J.
        • Arambepola C.
        • Sri Ranganathan S.
        • Sumanasena S.
        • Muhandiram E.
        The Efficacy of Moderate-to-High Dose Oral Prednisolone Versus Low-to-Moderate Dose Intramuscular Corticotropin for Improvement of Hypsarrhythmia in West Syndrome : A Randomized, Single-lind, Parallel Clinical Trial.
        Pediatr Neurol. 2014; 51: 24-30
        • Wanigasinghe J.
        • Arambepola C.
        • Sri Ranganathan S.
        • Sumanasena S.
        • Attanapola G.
        Randomized, Single-Blind, Parallel Clinical Trial on Efficacy of Oral Prednisolone Versus Intramuscular Corticotropin on Immediate and Continued Spasm Control in West Syndrome.
        Pediatr Neurol. 2015; https://doi.org/10.1016/j.pediatrneurol.2015.05.004
        • Kramer U.
        • Sue W.C.
        • Mikati M.A.
        Hypsarrhythmia : Frequency of variant patterns and correlation withetiology and outcome.
        Neurology. 1997; 48: 197-203
        • Hancock E.
        • Osborne J.
        • Milner P.
        Treatment of infantile spasms.
        Cochrane Database Syst Rev. 2003; : CD001770https://doi.org/10.1002/14651858.CD001770
        • Lux A.L.
        Is hypsarrhythmia a form of non-convulsive status epilepticus in infants?.
        Acta Neurol Scand. 2007; 115: 37-44https://doi.org/10.1111/j.1600-0404.2007.00808.x
        • Philippi H.
        • Wohlrab G.
        • Bettendorf U.
        • et al.
        Electroencephalographic evolution of hypsarrhythmia: toward an early treatment option.
        Epilepsia. 2008; 49: 1859-1864https://doi.org/10.1111/j.1528-1167.2008.01715.x

      Linked Article

      • Oral Prednisolone Versus Intramuscular Corticotropin in West Syndrome
        Pediatric NeurologyVol. 64
        • Preview
          West syndrome is a catastrophic and common epileptic syndrome. There are lots of uncertainties and consequent differences in treatment protocols for West syndrome arising from a paucity of scientific evidence1 especially with regards to first-line agents, i.e., corticosteroids versus adrenocorticotropic hormone versus vigabatrin. The familiarity of usage, easy availability, and inexpensive nature of prednisolone is lucrative especially for physicians working in underserved regions of developing economies.
        • Full-Text
        • PDF