As a rare and disabling neurological sleep disorder that is often diagnosed during
adolescence, narcolepsy type 1 (NT1) has been described as a relatively homogeneous
clinical syndrome of hypothalamic deficiency in hypocretin-1 (orexin) producing neurons.
1
,
2
As up to 98% of patients are human leukocyte antigen DQB1*06:02 positive, an autoimmune-mediated
hypothesis has been supported.
3
The core features include excessive daytime sleepiness (EDS), cataplexy, fragmented
nocturnal sleep with vivid dreams, and hallucinations and sleep paralysis during sleep-wake
transitions. Commonly, adolescents experience concurrent depression, stigmatization
from peers, and their body mass index is higher than 98th percentile.
4
Keywords
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Article info
Publication history
Published online: January 19, 2018
Accepted:
January 8,
2018
Received:
September 14,
2017
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
