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- Acute intrathecal baclofen withdrawal: a brief review of treatment options.Neurocrit Care. 2011; 14: 103-108
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The results of this investigation have been presented in part at annual meetings of the American Congress of Rehabilitation Medicine in Atlanta, GA, 2017 and the Association of Academic Physiatry in San Juan, Puerto Rico, 2019.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
There was no funding for this study.
Author Disclosures: Drs Coles, Krach, Kriel, and Schmitz have nothing to disclose. Dr Schrogie reports personal fees from Allaysis, LLC. during the conduct of the study and outside of the submitted work. In addition, Dr Schrogie has a patent pending for IV baclofen. Dr Cloyd reports that the University of Minnesota has a licensing agreement with Allaysis LLC. related to the development of IV baclofen and will receive royalty payments should IV baclofen be commercialized.
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- The Neurological Manifestations of Phelan-McDermid SyndromePediatric NeurologyVol. 122
- PreviewPhelan-McDermid syndrome (PMS) is a genetic disorder, caused by haploinsufficiency of the SHANK3 gene on chromosome 22q13.3. PMS is characterized by neurobehavioral symptoms and signs including intellectual disability, speech and language impairment, autism spectrum disorder (ASD), hypotonia, and other motor abnormalities. In the brain, SHANK3 is expressed in neurons, especially in the synapse, and encodes a master scaffolding protein that forms a key framework in the postsynaptic density of glutamatergic synapses.
- Kenneth Swaiman: A Festschrift to Honor His LegacyPediatric NeurologyVol. 122
- The Names of Things: The 2018 Bernard Sachs LecturePediatric NeurologyVol. 122
- PreviewIn 2018, I was honored to receive the Bernard Sachs Award for a lifetime of work expanding knowledge of diverse neurodevelopmental disorders. Summarizing work over more than 30 years is difficult but is an opportunity to chronicle the dramatic changes in the medical and scientific world that have transformed the field of Child Neurology over this time, as reflected in my own work. Here I have chosen to highlight five broad themes of my research beginning with my interest in descriptive terms that drive wider understanding and my choice for the title of this review.
- A Relentless Commitment to the Children We ServePediatric NeurologyVol. 122
- Discovery of Glut 1 Deficiency Syndrome: Cerebrospinal Fluid Inspiration and SerendipityPediatric NeurologyVol. 122
- PreviewI am pleased to present this article in memory and honor of my mentor, Kenneth F. Swaiman. Steve Roach and Stephen Ashwal inspired me to describe and publish the backstory of the discovery of Glut 1 deficiency syndrome (Glut1DS) based on a talk I gave for the Bresnan course in Boston in 2016 for the twenty-fifth anniversary of the Glut1DS publication in the New England Journal of Medicine.1 In doing so, this will also reference my relationship with Kenneth F. Swaiman and my training at the University of Minnesota 1979 through 1982 and the next two years as a faculty member with adjoining offices with Ken.
- Post-traumatic Neuroinflammation: Relevance to PediatricsPediatric NeurologyVol. 122
- PreviewBoth detrimental and beneficial effects of post-traumatic neuroinflammation have become a major research focus as they offer the potential for immediate as well as delayed targeted reparative therapies. Understanding the complex interactions of central and peripheral immunocompetent cells as well as their mediators on brain injury and recovery is complicated by the temporal, regional, and developmental differences in their response to injuries. Microglia, the brain-resident macrophages, have become central in these investigations as they serve a major surveillance function, have the ability to react swiftly to injury, recruit various cellular and chemical mediators, and monitor the reparative/degenerative processes.
- Pediatric Neurology at the Boston City Hospital: the Early Years (1969 to 1986)Pediatric NeurologyVol. 122
- PreviewAs I look back at my years at Boston City Hospital (BCH), I am reminded that this festschrift is in honor of Ken Swaiman, of whom I was a long-time friend and admirer. As almost everyone recognizes, Ken had an enormous impact on how child neurology developed and one of the ways he did this was his personal involvement with many of us that had lifelong effects on our careers and personal lives. At the end of my seventh year in the Child Neurology Society (CNS), I was one of two nominees to assume its presidency (1978 to 1979).
- Kenneth Swaiman in Minnesota: Personal ReflectionsPediatric NeurologyVol. 122
- PreviewKenneth Swaiman entered my life in July 1963. I was in my first month as a pediatric intern working to acquire basic skills. Ken, early in his first faculty appointment, swept onto my ward with his entourage of trainees to consult on one of the patients. My inexperience did not allow me to appreciate all of what transpired that day, but the recommendations about the patient were helpful. My professional relationship with Ken started that day and endured until his retirement. Therefore I welcome an opportunity to describe him from our lengthy association.