- •Mutant load varies significantly in patients with mtDNA-associated Leigh Syndrome
- •MT-ATP6, MT-ND3, and MT-ND5 are the most common mutations
- •MT-ATP6 had a significantly higher mutant load than that of MT-ND3 and MT-ND5
- •Distribution of the heteroplasmic mutant load depends on the mutated gene
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Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea [grant numbers: 2018-31-0425/HI18C1166020018, 2018-31-1061/HI18C1166020019, 2019-31-1183/HI18C1166020020].
YL contributed to the conception and designed the study. JN analyzed and interpreted the data and wrote the manuscript. All authors have read and agreed to the published version of the manuscript.